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. 2022 Jan 21;13(1):73. doi: 10.1038/s41419-022-04524-2

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — NKAP functions as an m⁶A reader and recruits a splicing complex to promote the TTS event on the SLC7A11 transcript to produce mature mRNA. SLC7A11 anchored in the cytomembrane mediates the entry of cystine to generate GSH, which can neutralize PLOOH and ROS and eventually prevents ferroptosis.