Fig. 10.

bMIPCs generate OBiN-IPCs in the human cortex. A EGFR, GSX2 and OLIG2 triple immunostained GW23 cortical section. Note that GSX2⁺ cells were mainly in the cortical IFL. B Higher magnification images showing that a subset of EGFR⁺OLIG2⁺ bMIPCs expressed GSX2 (arrows). We noted that a few EGFR⁺GSX2⁺ cells already downregulated OLIG2 expression (arrowheads). C EGFR⁺ASCL1⁺DLX2⁺ cells (OBiN-IPCs) were shown (arrows). D Schema summarizing scRNA-Seq analysis and immunohistochemistry results described in the paper. Human cortical bMIPC population give rise to cortical OPCs, APCs and OBiN-IPCs.