Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 10;38(1):47–68. doi: 10.1007/s12264-021-00759-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — vRGs, tRGs and oRGs coexist in the human cortex at GW17-GW18. A scRNA-Seq analysis of 33,976 cortical cells from the mid-gestation human brain (GW17-GW18) [36]. B, C Expression patterns of PDGFD (vRG and tRG marker), HOPX, FAM107A, LIFR, ALDOC, AQP4, BCAN, GFAP and TNC indicated the coexistence of cortical vRGs, tRGs and oRGs. D EGFR, ASCL1, ANXA1, CRYAB and CXCL12 were expressed in tRGs but not in oRGs or vRGs. Note that EGFR was weakly expressed in a subpopulation of PyN-IPCs, and ASCL1 was expressed (indicated by arrows) in a subpopulation of PyN-IPCs, maturing PyNs, and MGE- and CGE-derived cortical interneurons, and MGE-derived OPCs. E ACSBG1 and FBN2 were expressed in oRGs but not in tRGs. F Wide expression of PyN-IPC marker genes (PAX6, NEUROG2 and EOMES) indicating activated PyN genesis. G Except MGE-derived OPCs, cortex-derived OPC or APC clusters were not identified, suggesting that gliogenesis had not commenced yet in the human cortex at GW17-GW18.