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. 2021 Dec 31;24:355–370. doi: 10.1016/j.omto.2021.12.021

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

SNHG26 inhibits PGK1 ubiquitination in TSCC cells

(A) mRNA levels of PGK1 were not significantly different when SNHG26 was silenced or overexpressed in TSCC cells. (B) Protein levels of PGK1 were reduced in CAL27 and SCC15 cells when SNHG26 was silenced and were upregulated in CAL27 and SCC15 cells when SNHG26 was overexpressed. (C) Knockdown of SNHG26 significantly decreased the half-life of PGK1. (D) Overexpression of SNHG26 in CAL27 and SCC15 had similar effect as addition of MG-132. (E) Co-IP assay showed that ubiquitination of PGK1 in CAL27 and SCC15 cells was significantly increased by SNHG26 knockdown. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.