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. 2021 Dec 31;24:355–370. doi: 10.1016/j.omto.2021.12.021

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

SNHG26 regulates the Akt/mTOR signaling pathway via PGK1 to affect proliferation and EMT-related protein expression

(A) STRING and TCGA-HNSC databases showed that PGK1 could interact with AKt/mTOR pathway and has a positive co-expression relationship. (B and C) WB experiment confirmed that PGK1 and SNHG26 could improve the phosphorylation level of Akt/mTOR. (D) The addition of mTOR activator (MHY1485) could reverse the effects of SNHG26 knockdown on proliferation and EMT-related proteins. (E) Overexpression of PGK1 could reverse the effects of SNHG26 knockdown on proliferation and EMT-related proteins.