Figure 12.

A model for the effects of H2R signaling on neutrophil function during tumor development. Bone marrow–derived mature and immature neutrophils infiltrate tumor tissues, contributing to cancer development by suppressing effector T cells, secreting factors including HDGF and up-regulating PD-L1 expression in tumor cells through IL1β. Disruption of H2R signaling in neutrophils enhances permissiveness toward cancer development, leading to accelerated tumor development and progression. The thick orange arrows indicate enhanced production, while the thindark greenarrows indicate baseline production.