Table 3.

Diameter, Circumference, and Areas of LDs Evaluated by TEM Analysis and Stratified According to the Genetic Background of the HepG2 Cells

	Diameter	ANOVA	Student t test	P valuea
Cas9+	0.38 {0.33–0.43}	<0.0001
MBOAT7-/-	2.88 {2.59–3.18}	<0.0001	<0.0001	<.0001
TM6SF2-/-	1.05 {0.91–1.16}	<0.0001	<0.0001	<.0001
MBOAT7-/-TM6SF2-/-	2.42 {2.04–2.72}	<0.0001	<0.0001	<.0001

	Circumference, μm
Cas9+	1.19 {1.05–1.35}	<0.0001
MBOAT7-/-	9.09 {8.13–10.0}	<0.0001	<0.0001	<.0001
TM6SF2-/-	3.31 {2.87–3.65}	<0.0001	<0.0001	<.0001
MBOAT7-/-TM6SF2-/-	7.60 {6.42–8.55}	<0.0001	<0.0001	<.0001

	Area, μm2
Cas9+	0.11 {0.09–0.14}	<0.0001
MBOAT7-/-	6.51 {5.26–7.98}	<0.0001	<0.0001	<.0001
TM6SF2-/-	0.87 {0.65–1.06}	<0.0001	0.003	<.0001
MBOAT7-/-TM6SF2-/-	4.60 {3.28–5.82}	<0.0001	<0.0001	<.0001

NOTE. Values are reported as median {interquartile range}.

^aBold P values are adjusted at post hoc Dunn's multiple comparison test and compared with the Cas9⁺ control group.