Table 4.
ER Cisternae Width and Area of Golgi Apparatus Calculated From TEM Micrographs and Stratified According to the Genetic Background of the HepG2 Cells
| ER width, μm | ANOVA | Student t test | P valuea | |
|---|---|---|---|---|
| Cas9+ | 0.09 {0.07–0.13} | <0.0001 | ||
| MBOAT7-/- | 0.18 {0.14–0.25} | <0.0001 | <0.0001 | <.0001 |
| TM6SF2-/- | 0.30 {0.23–0.37} | <0.0001 | <0.0001 | <.0001 |
| MBOAT7-/-TM6SF2-/- | 0.35 {0.27–0.44} | <0.0001 | <0.0001 | <.0001 |
| Golgi body area, μm2 | ||||
|---|---|---|---|---|
| Cas9+ | 0.007 {0.005–0.010} | <0.0001 | ||
| MBOAT7-/- | 0.026 {0.023–0.028} | <0.0001 | <0.0001 | <.0001 |
| TM6SF2-/- | 0.030 {0.027–0.033} | <0.0001 | <0.0001 | <.0001 |
| MBOAT7-/-TM6SF2-/- | 0.036 {0.033–0.039} | <0.0001 | <0.0001 | <.0001 |
NOTE. Values are reported as median {interquartile range}.
a
Bold P values are adjusted at post hoc Dunn’s multiple comparison test and compared with the Cas9+ control group.