FIGURE 6.

Effect of sham, uninephrectomy or 5/6^th nephrectomy on urinary extracellular vesicle (uEV) excretion in rats. (a) 24‐h uEV excretion before (Pre) and 8 weeks after (Post) sham surgery (n = 10) and uEV size distribution (right panel, ± SEM per 1 nm bin size); (b) 24‐h uEV excretion before and 8 weeks after uninephrectomy (n = 8) and uEV size distribution (lower panel, ± SEM per 1 nm bin size); (c) 24‐h uEV excretion before and 8 weeks after 5/6^th nephrectomy (n = 8) and uEV size distribution (lower panel, ± SEM per 1 nm bin size); (d) Percentage change in uEV excretion before‐after sham surgery, uninephrectomy or 5/6^th nephrectomy, including uEV size distribution (right panel, ± SEM per 1 nm size bin); (e) Spearman correlation between the change in uEV excretion and FITC‐sinistrin glomerular filtration rate (GFR); •, sham surgery; ○ uninephrectomy; □ 5/6^th nephrectomy; f) Spearman correlation between the change in 24‐h uEV excretion and kidney weight. *p ≤ 0.05, **p < 0.01, ***P < 0.001