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. 2021 Mar 5;117(13):2652–2663. doi: 10.1093/cvr/cvab074

Figure 3.

Figure 3

Physicochemical characterization of Col IV-targeting NPs. (A) Dynamic light scattering (DLS) analysis of empty and GSK484 (GSK)-loaded Col IV-NPs reveals a slight increase of the hydrodynamic size after GSK encapsulation (64 and 94 nm for empty and GSK Col IV-NPs, respectively). GSK encapsulation did not significantly affect the homogeneity of the formulations, as indicated by the polydispersity index values before and after GSK encapsulation (PDI = 0.24 and 0.23, respectively). (B) Zeta potential analysis reveals a negative surface charge for both empty and GSK-loaded Col IV-NPs, without significant changes after GSK encapsulation. (C) Representative TEM images of GSK NPs and Col IV GSK NPs validates DLS analysis. (D) Cumulative release of GSK from Col IV NPs at 37°C.