Fig.3.

Representative histological appearance treated with preoperative chemotherapy (Hematoxylin and eosin stain, original magnification × 400): a. Viable tumor cells with slight nuclear swelling. b. Non-viable tumor cells showing degenerative change. The tumor cells changed into large, bizarre and multinucleated cells with vacuolated chromatin. c. Non-viable tumor cells with pyknosis, karyorrhexis and karyolysis. d. Necrotic tumor cells with loss of nuclear staining. e. fibrosis and hyalinized stroma. f. Intratumoral cystic change