Table 1.
Comparison of clinical and laboratory data among subgroups of patients with T2DM divided according to UACR and healthy subjects
| Heathy controls (n = 45) | Normo albuminuria (n = 121) | Micro albuminuria (n = 73) | Macro albuminuria (n = 25) | aP-value | bP-value | |
|---|---|---|---|---|---|---|
| Male, n (%) | 26(57.8%) | 72(59.5%) | 38(52.1%) | 15(60.0%) | 0.768 | 0.568 |
| Age (years) | 63.40 ± 10.38 | 62.51 ± 10.34 | 65.18 ± 13.52 | 64.48 ± 10.85 | 0.445 | 0.277 |
| SBP (mmHg) | 117.44 ± 7.04 | 129.50 ± 12.15&& | 132.12 ± 14.41&& | 141.60 ± 17.68&&**# | < 0.001 | < 0.001 |
| DBP (mmHg) | 74.00 ± 6.79 | 79.41 ± 7.76&& | 78.96 ± 9.47& | 79.88 ± 6.70& | 0.001 | 0.874 |
| FBG (mmol/L) | 4.81 ± 0.42 | 8.63 ± 4.14&& | 8.79 ± 3.50&& | 9.10 ± 2.76&& | < 0.001 | 0.850 |
| HbA1c (%) | 5.50 ± 0.37 | 9.41 ± 2.40&& | 9.88 ± 3.19&& | 9.45 ± 2.17&& | < 0.001 | 0.479 |
| Known diabetes duration (years) | / | 8.00(3.00, 15.00) | 10.00(6.00, 20.00)** | 18.00(13.00, 20.00)**# | / | < 0.001 |
| UACR (mg/g) | 3.59(2.04, 5.75) | 8.55(5.30, 14.07)&& | 77.69(48.49, 166.00)&&** | 834.05(614.33, 2103.99)&&**## | < 0.001 | < 0.001 |
| sCr (umol/L) | 66.73 ± 12.19 | 65.07 ± 13.82 | 72.07 ± 18.48* | 137.04 ± 49.66&&**## | < 0.001 | < 0.001 |
| BUN (mmol/L) | 5.11 ± 0.96 | 5.58 ± 1.45 | 7.08 ± 2.81&&** | 8.91 ± 4.33&&**# | < 0.001 | < 0.001 |
| sUA (ummol/L) | 308.84 ± 71.81 | 325.74 ± 94.77 | 345.77 ± 101.29& | 373.84 ± 103.01&* | 0.022 | 0.060 |
| eGFR (ml/min/1.73 m2) | 102.44 ± 21.80 | 106.44 ± 21.12 | 95.31 ± 28.75* | 47.53 ± 12.50&&**## | < 0.001 | < 0.001 |
| TC (mmol/L) | 4.67 ± 0.72 | 4.68 ± 1.59 | 4.38 ± 1.22 | 4.41 ± 1.38 | 0.421 | 0.335 |
| TG (mmol/L) | 0.94(0.75, 1.33) | 1.55(1.08, 2.43)& | 1.40(0.99, 2.12)& | 1.66(1.13, 2.63)& | < 0.001 | 0.360 |
| LDL-C (mmol/L) | 2.97 ± 0.84 | 2.93 ± 1.15 | 2.69 ± 0.84 | 2.84 ± 1.00 | 0.373 | 0.319 |
| HDL-C (mmol/L) | 1.41 ± 0.28 | 1.13 ± 0.35&& | 1.11 ± 0.31&& | 1.06 ± 0.27&& | < 0.001 | 0.660 |
| CgA (ng/mL) | 1.89(1.42, 2.47) | 2.26(1.38, 4.12)& | 4.83(2.63, 6.46)&&** | 6.35(4.91, 7.54)&&**# | < 0.001 | < 0.001 |
| ACEI/ARB, n (%) | 0(0.0%) | 34(28.1%)&& | 25(34.2%)&& | 18(72.0%)&&**# | < 0.001 | < 0.001 |
Notes
SBP systolic blood pressure, DBP diastolic blood pressure, FBG fasting blood glucose, HbA1c hemoglobin A1c, UACR urine albumin to creatinine ratio, sCr serum creatinine, BUN blood urea nitrogen, sUA serum uric acid, eGFR estimated glomerular filtration rate, TC total cholesterol, TG triglyceride, LDL-C low density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol, CgA Chromogranin A
aP-value: comparisons among the healthy controls group, the normoalbuminuria group, the microalbuminuria group and the macroalbuminuria group;
bP-value: comparisons among the normoalbuminuria group, the microalbuminuria group and the macroalbuminuria group
&P < 0.05
&&P < 0.001 vs. healthy controls
*P < 0.05
**P < 0.001 vs. normoalbuminuria group
#P < 0.05
##P < 0.001 vs. microalbuminuria group