Table 3.
Cox proportional hazards 10-year overall survival models
| n (%) deceased | n (%) alive | Survival months | Multivariable model | ||
|---|---|---|---|---|---|
| Mean# | HR (95% CI) | P value | |||
| Age | 180 (29.9) | 423 (70.1) | 104.3 | 1.07 (1.04–1.08) | 8.7E−9 |
| Sex | |||||
| Male | 156 (34.1) | 301 (65.9) | 102.2 | Referent group | |
| Female | 24 (16.4) | 122 (83.6) | 111.1 | 0.62 (0.40–0.96) | 0.032 |
| Tumor grade | |||||
| 1 + 2 | 118 (26.1) | 334 (73.9) | 106.6 | Referent group | |
| 3 + 4 | 62 (41.1) | 89 (58.9) | 97.7 | 1.54 (1.12–2.12) | 8.0E−3 |
| Smoking status | |||||
| Non-smoker | 19 (18.4) | 84 (81.6) | 110.8 | Referent group | |
| Ever-smoker | 161 (32.2) | 339 (67.8) | 103.0 | 1.66 (1.03–2.67) | 0.039 |
| BCG treatment | |||||
| No | 152 (29.6) | 362 (70.4) | 104.8 | Referent group | |
| Yes | 28 (31.5) | 61 (68.5) | 101.9 | 1.04 (0.68–1.60) | 0.842 |
| mdNLR* | 180 (29.9) | 423 (70.1) | 104.3 | 1.46 (1.32–1.60) | 6.0E−15 |
HR: hazard ratio, CI: confidence interval, mdNLR: methylation-derived neutrophil to lymphocyte ratio
*Winsorization was used on the top 2% values for fitting linearity assumption
All covariates modeled met proportionality assumptions #: the median survival month for each variable is 120