Table 1.
Demographic composition of the brain donor cohort, primary and secondary post-mortem diagnoses, and global neuropathological staging using the Hyman et al.10 protocol
| Brain donor cohort | ||||
|---|---|---|---|---|
| n | 18 | |||
| Age | 75.2 ± 11.4 | 45–93 | ||
| Sex, female:male | 7:11 | |||
|
| ||||
| Diagnosis (from contralateral sampling) | Primary | Secondary | ||
|
| ||||
| Unremarkable brain | 1 | – | ||
| Primary age-related pathology (PART) | 4 | – | ||
| Low ADNC | 6 | 1 | ||
| Intermediate ADNC | 1 | – | ||
| Corticobasal degeneration (CBD) | 2 | 1 | ||
| Lewy body disease (LBD) | 1 | 2 | ||
| Argyrophilic grain disease (AGD) | 1 | – | ||
| Frontotemporal lobar degeneration (TDP-43 type) | 1 | 1 | ||
| Cerebrovascular disease (CVD) | 1 | 1 | ||
| Progressive supranuclear palsy (PSP) | – | 1 | ||
|
| ||||
| Neuropathological staging (from contralateral sampling) | Stage | |||
| 0 | 1 | 2 | 3 | |
|
| ||||
| Amyloid (A) | 7 | 10 | 0 | 1 |
| Braak (B)a | 3 | 10 | 4 | 0 |
| CERAD (C) | 13 | 4 | 0 | 1 |
| α-Synuclein | 15 | 2 | 1 | 0 |
| TDP-43 | 16 | 0 | 0 | 2 |
Staging and diagnoses were derived from the opposite hemisphere from the one scanned with MRI. ADNC = Alzheimer’s disease neuropathological change.
a
For the brain donor with the diagnosis of argyrophilic grain disease, the Braak (B) score was undeterminable.