Table 4.
Quantitative analysis of in vivo Far-Red decay and in vitro NT-3 protein release from PEG and Poloxamer 407 hydrogels.
| Far-Red fluorescence reduction in vivo | Cumulative NT-3 release in vitro | |||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| 20% PEG | 20% Poloxamer | Dye solution | 10% PEG | 15% PEG | 20% PEG | 20% PEG with peptides 2 | 20% Poloxamer | |
|
| ||||||||
| 1 K | 1.1 d−1 | 5.3 d−1 | 9.7 d−1 | 4.5 d−1 | 3.9 d−1 | 3.1 d−1 | 1.1 d−1 | 13.8 d−1 |
1
K: kinetic rate constant calculated from equation (5).
2
NLKEPYA peptides are conjugated to PEG hydrogels at a peptide: NT-3 = 50: 1 molar ratio.