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. 2022 Jan 22;29(6):3726–3736. doi: 10.1245/s10434-021-11295-1

Table 2.

Protocol deviations and treatment

Protocol deviation groups Treatment after protocol deviations
Re-excision Alone Re-excision + WBRT WBRT alone Mastectomy Refused additional treatment Number patients
Margin 30 3 21 4 87 145
Margin, node 0 0 0 0 1 1
Margin, node, size 0 1 2 1 1 5
Margin, size 7 6 24 10 19 66
Margin, LVI 1 0 4 0 0 5
Margin, LVI, size 0 0 1 0 0 1
Margin, multifocal, node 0 1 0 0 0 1
Margin, multifocal, size 0 1 0 0 0 1
Node 0 0 25 0 4 29
Node, size 0 0 5 0 1 6
Node, LVI 0 0 5 0 0 5
Node, LVI, size 0 0 2 0 0 2
Size 0 0 54 2 48 104
Size, multifocal 0 0 2 0 1 3
Multifocal 0 1 0 0 1 2
LVI 0 0 4 1 28 33
Total 38 13 149 18 191 409

409 patients experienced 1 or more protocol violations. They redivided into 16 groups