Skip to main content
. 2021 Dec 22;6(24):e150451. doi: 10.1172/jci.insight.150451

Figure 2. Bioinformatics analysis unravels an undiscovered link between hypoxia and DOT1L.

Figure 2

(A) STRINGdb protein-protein network of the 18 resulting transcription factors (TFs) upon the specificity analysis. (B and C) Cartilage-specific gene network of the 18 resulting TFs upon the specificity analysis using HumanBase (GIANT) (B) and its pathway enrichment analysis (C). (D) Presence of tandem hypoxia-response elements (HREs) with consensus sequence 5′-(A/G)CGTG-3′ (highlighted with yellow boxes) within the human, mouse, and rat DOT1L gene promoters.