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. 2021 Dec 22;6(24):e154093. doi: 10.1172/jci.insight.154093

Figure 4. NHP fetal liver macrophage count and function.

Figure 4

(A) Representative images of CD68-stained portal triad (PT) regions in CD- and WSD-exposed fetal liver tissue. Scale bar: 100 μm (boxed area is enlarged and cropped on the right). (B) CD68 staining quantification showing numbers of periportal CD68+ macrophages in CD (blue) and WSD (yellow) exposed fetal livers; n = 8 CD and n = 6 WSD. Unpaired 2-tailed Student’s t test was used to test significance. Liver macrophage gene expression of IL1B (C) and TNF (D) at baseline and in response to LPS; n = 7 CD and n = 10 WSD. A mixed model 2-way ANOVA was used to test effect of maternal diet and LPS treatment. Maternal effect and treatment effect P values are shown, and LPS x maternal diet interaction effect P values are shown above WSD bars.