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. 2021 Dec 22;6(24):e150112. doi: 10.1172/jci.insight.150112

Figure 2. Collagen content and density are progressively elevated in skeletal muscle of patients with CKD.

Figure 2

Proportion of ECM collagen content is elevated in CKD patients (A) and negatively associated with eGFR (B) (n = 33). Densely packed collagen content is elevated in CKD patients (C) and negatively associated with eGFR (D) (n = 33). Loosely packed collagen content was numerically higher but not significantly different in CKD patients (E) and not significantly correlated with eGFR (F) (n = 33). Representative images of picrosirius red staining in control and CKD muscle under both bright-field and polarized light (G). Total skeletal muscle collagen content assayed biochemically is elevated in CKD patients (H) and negatively associated with GFR (I) (n = 28). Comparisons made using 2-tailed t tests or Wilcoxon rank-sum tests. Spearman coefficients calculated to test correlations. Scale bar: 100 μm. *P < 0.05, control compared with CKD.