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. 2021 Dec 22;6(24):e147170. doi: 10.1172/jci.insight.147170

Figure 4. Differential retrotranscriptome profiling of RNA-Seq data from clinical samples from donors with COVID-19.

Figure 4

Volcano plots of differentially expressed TEs from BALF samples from donors with COVID-19 compared with healthy donors separated by (A) HERVs and (B) LINE-1 elements. Volcano plots of differentially expressed TEs from PBMCs of patients with COVID-19 compared with healthy donors separated by (C) HERVs and (D) LINE-1 elements. (E) Upset plot of differentially expressed retroelement intersections across SARS-CoV-2 (COV2) infections of Calu-3 cells, A549 cells, A549-ACE2 cells, and BALF and PBMCs from clinical samples of patients with severe COVID-19.