Table 2.
The degree centrality (DC), betweenness centrality (BC), and closeness centrality (CC) values of the key targets for TTNC in treating migraine.
| No. | Gene name | Target name | CC | DC | BC |
|---|---|---|---|---|---|
| 1 | AKT1 | AKT serine/threonine kinase 1 | 0.4345 | 24 | 0.1875 |
| 2 | ESR1 | Estrogen receptor 1 | 0.3544 | 20 | 0.0592 |
| 3 | ESR2 | Estrogen receptor 2 | 0.3427 | 18 | 0.0394 |
| 4 | AR | Androgen receptor | 0.3318 | 18 | 0.0887 |
| 5 | DNMT1 | DNA methyltransferase 1 | 0.3862 | 18 | 0.1141 |
| 6 | HRAS | HRas proto-oncogene, GTPase | 0.3596 | 11 | 0.0450 |
| 7 | CYP19A1 | Cytochrome P450 family 19 subfamily a member 1 | 0.2967 | 10 | 0.0123 |
| 8 | NOS1 | Nitric oxide synthase, brain | 0.3782 | 10 | 0.0583 |
| 9 | HTR1F | 5-Hydroxytryptamine receptor 1F | 0.2908 | 9 | 0.0112 |
| 10 | HTR2A | 5-Hydroxytryptamine receptor 2A | 0.2920 | 9 | 0.0192 |
| 11 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 0.3510 | 9 | 0.0241 |
| 12 | PTGS2 | Prostaglandin G/H synthase 2 | 0.3349 | 9 | 0.0471 |
| 13 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | 0.3460 | 8 | 0.0187 |
| 14 | HTR1A | 5-Hydroxytryptamine receptor 1A | 0.3042 | 8 | 0.0220 |
| 15 | INS | Insulin | 0.2920 | 7 | 0.0089 |
| 16 | SRC | Proto-oncogene tyrosine-protein kinase Src | 0.3333 | 7 | 0.0160 |
| 17 | DRD2 | D(2) dopamine receptor | 0.3364 | 6 | 0.0205 |
| 18 | EDNRA | Endothelin-1 receptor | 0.3160 | 6 | 0.0127 |
| 19 | IGF1R | Insulin-like growth factor 1 receptor | 0.3318 | 6 | 0.0117 |
| 20 | INSR | Insulin receptor | 0.3333 | 6 | 0.0105 |