Table 3.
The degree centrality (DC), betweenness centrality (BC), and closeness centrality (CC) values of the key pathways for TTNC in treating migraine.
| No. | Pathway | Targets | CC | DC | BC |
|---|---|---|---|---|---|
| 1 | cAMP signaling pathway | ADORA1, AKT1, CFTR, CREB1, DRD2, EDNRA, HTR1A, HTR1F, NFKB1, NFKBIA, PIK3CA, PPARA | 0.3436 | 12 | 0.0524 |
| 2 | Retrograde endocannabinoid signaling | ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFB3, NDUFB8, NDUFV2, PTGS2 | 0.3085 | 12 | 0.0321 |
| 3 | PI3K-Akt signaling pathway | AKT1, CREB1, EGF, HRAS, IGF1R, IL4, INS, INSR, ITGB3, NFKB1, PIK3CA, TP53 | 0.3356 | 12 | 0.0394 |
| 4 | Rap1 signaling pathway | AKT1, DRD2, EGF, HRAS, IGF1R, INS, INSR, ITGB3, PIK3CA, SRC | 0.3281 | 10 | 0.0246 |
| 5 | Estrogen signaling pathway | AKT1, CREB1, ESR1, ESR2, HRAS, PIK3CA, SRC | 0.3311 | 8 | 0.0263 |
| 6 | cGMP-PKG signaling pathway | ADORA1, AKT1, SLC25A4, CREB1, EDNRA, INS, INSR | 0.3208 | 7 | 0.0125 |