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. 2022 Jan 15;2022:9947191. doi: 10.1155/2022/9947191

Figure 1.

Figure 1

Therapeutical effects of PD on attenuating renal injury in Cis-AKI mice. (a) Mice pretreated with PD (40 mg/kg) or Fer-1 (5 mg/kg) were administered with intraperitoneal injections of cisplatin (20 mg/kg), and either PD or Fer-1 was intraperitoneally reinjected at 24 h after cisplatin injection. They were executed 48 h after the cisplatin injection. (b–d) Body weight changes, BUN, and Scr were measured at 48 h after injection of cisplatin. (e, f) Histopathology analysis of the kidneys in Cis-AKI mice was performed by hematoxylin-eosin (H&E) staining (400x magnification), and the HSK was graded. (g) Representative terminal deoxynucleotidyl transferase dUTP nick-end labeling- (TUNEL-) stained sections of the kidney (200x magnification). ∗P < 0.05, ∗∗P < 0.01 vs. control; #P < 0.05, ##P < 0.01 vs. cisplatin; $P < 0.05, $$P < 0.01 vs. Cis+PD (n = 5 to 7). Cis: cisplatin; PD: polydatin; Fer-1: ferrostatin-1; BUN: blood urea nitrogen; Scr: serum creatinine; HSK: histological score of kidney injuries.