Date	Event	Description
28 November 2012	New citation required and conclusions have changed	Summary of most important changes in the update: The search for eligible studies was updated to June 2012. Additional follow‐up data of one of the three already included RCTs were available. For overall survival the results changed from a significant difference in favour of myeloablative therapy into no significant difference between the treatment groups. It should be noted that all included studies used an age of one year as the cut‐off point for pre‐treatment risk stratification. Recently the age cut‐off for high risk disease was changed from one year to 18 months. As a result it is possible that patients with what is now classified as intermediate risk disease have been included in the high risk groups. Consequently the relevance of the results of these studies to the current practice can be questioned.
28 November 2012	New search has been performed	The search for eligible studies was updated to June 2012.