3. The effects of n‐3 LCPUFA supplementation on skin prick results for allergens using pooled analysis RR (M‐H, Fixed, 95% CI).

Skin prick results	Assessed Age	No of studies	No of participants	n‐3 LCPUFA		Placebo		Fixed Effect estimate RR [95% CI]
				Events	Total	Events	Total
Egg	< 12 months	2	203	7	100	17	103	0.44 [0.19 to 1.04]
	12‐36 months	3	893	46	455	82	438	0.55 [0.39 to 0.77] ٭٭
	≥ 36 months	1	706	11	368	16	338	0.63 [0.30 to 1.34]
Cow’s milk	< 12 months	2	205	5	102	7	103	0.75 [0.24 to 2.29]R
	12‐36 months	3	897	9	457	13	440	0.68 [0.20 to 2.34]R
	≥ 36 months	0	0					NE
Peanut	< 12 months	0	0					NE
	12‐36 months	2	778	18	403	28	375	0.61 [0.34 to 1.08]
	≥ 36 months	1	706	13	368	20	338	0.60 [0.30 to 1.18]
Wheat	< 12 months	1	117	1	52	0	65	3.74 [0.16 to 89.85]
	12‐36 months	2	783	3	401	2	382	1.40 [0.29 to 6.84]
	≥ 36 months	1	706	6	368	2	338	2.76 [0.56 to 13.56]
Fish	< 12 months	0	0					NE
	12‐36 months	1	666	3	349	0	317	6.36 [0.33 to 122.65]
	≥ 36 months	1	706	2	368	1	338	1.84 [0.17 to 20.17]
Inhalant allergens (pollens)	< 12 months	0	0					NE
	12‐36 months	2	779	2	400	5	379	0.44 [0.08 to 2.30]
	≥ 36 months	1	580	21	303	25	277	0.77 [0.44 to 1.34]
House dust mite	<12 months	0	0					NE
	12‐36 months	2	738	3	384	4	354	0.76 [0.18 to 3.28]
	≥36 months	1	580	22	303	24	277	0.84 [0.48 to 1.46]
Cat	< 12 months	1	86	1	48	1	38	0.79 [0.05 to 12.25]
	12‐36 months	2	738	8	384	7	354	1.07 [0.39 to 2.94]
	≥ 36 months	1	706	25	368	12	338	1.91 [0.98 to 3.75]
Any allergen (one or more allergen)	< 12 months	2	201	14	100	25	101	0.59 [0.32 to 1.09]
	12‐36 months	3	892	68	455	93	437	0.70 [0.53 to 0.94] ٭
	≥ 36 months	1	706	91	368	88	338	0.95 [0.74 to 1.22]

*significant P < 0.05, ٭٭ significant P < 0.005, NE = Not estimable