Noakes 2012.

Methods	Randomised controlled trial. Miles 2011 was the main trial with 13 reports. All 13 publications are included in the references to included studies.
Participants	Setting: United Kingdom. Women aged 18 to 40 years who were at 19 weeks' gestation with a healthy uncomplicated pregnancy who reported low habitual consumption of oily fish (2 portions/month excluding canned tuna and no use of fish oil supplements in previous 3 months) and had a family history of atopy (1 or more first‐degree relatives of the infant affected by atopy, asthma, or allergy) were recruited to the trial (n = 123). Excluded were those participating in another research study, known diabetes, autoimmune disease, learning disability, terminal illness or mental health problems.
Interventions	Intervention: women in the salmon group (n = 62) were asked to incorporate 2 portions of salmon (300 g) which contained 7.12 g total n‐3 LCPUFAs (1.14 g EPA/week and 2.32 g DHA/week) into their diet from week 20 (trial entry) until they gave birth. Women and their partners were provided with 2 portions of salmon per week to incorporate into their diet. They also received a cookbook that provided recipes for preparing and cooking salmon. Each portion of salmon was to replace a serve of protein (e.g. white fish, chicken or red meat). Control: women in the control group were asked to continue their habitual diets; these women received the information sheet that described the possible health benefits of consuming oily fish during pregnancy and the government recommendation that pregnant women consume 1 or 2 oily fish meals/week. They also received a cookbook providing recipes for healthy eating during pregnancy.
Outcomes	1. Miles 2011 reported Primary outcome ‐ determine the effect on maternal and umbilical cord plasma n‐3 LCPUFA content. 2. Noakes 2012 reported Effect on neonatal immune responses and diagnosis, by research nurse, of eczema and wheeze at 6 months of age. Chest infections and SPT at 6 months of age.
Notes	Supported by the European Commission under Framework 6: Sustainable aqua feeds to maximize the health benefits of farmed fish for consumers (Aquamax; FOOD‐CT‐2006‐16249). 2 researches were supported by the Southampton NIHR Biomedical Research Unit in Nutrition, Diet & Lifestyle. Salmon was donated by the University of Bergen, Norway.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote "The women were allocated to one of two groups according to a previously generated random number table".
Allocation concealment (selection bias)	Unclear risk	Not described.
Blinding of participants and personnel (performance bias) All outcomes	High risk	Participants were not blinded.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Researchers responsible for assessing outcome measures (both laboratory and clinical) remained blinded.
Incomplete outcome data (attrition bias) All outcomes	High risk	Enrolled 123 (62 salmon, 61 control). At delivery: 107 (87%): 53 (85%) salmon, 54 (89%) control. Birth samples: 101 (82%): 51 (82%) salmon, 50 (82%) control. 6‐month clinic visit: 86 (70%): 48 (77%) salmon, 38 (62%) control.
Selective reporting (reporting bias)	High risk	Trial registered at clinicaltrials.gov as NCT00801502. Only limited data were reported on some of the prespecified review outcomes.
Other bias	Low risk	There is no obvious risk of other bias.