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. 2021 Sep 6;61(1):477–487. doi: 10.1007/s00394-021-02666-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Schematic overview of the ERGO2 trial. The ketogenic diet/fasting group (KD-IF) started with a calorically restricted ketogenic diet on days 1–3. Patients fasted without calorie intake on days 4–6. Days 7–9 were again a calorically restricted ketogenic diet. Patients of the control group (SD) were counseled according to the recommendations of the German Society of Nutrition; no reduced calorie intake was desired. Radiation therapy (XRT) was planned from days 4 to 8 but final specification was left to the local radiation therapist. Figure adapted from [21]