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. 2021 Jun 14;71(2):251–265. doi: 10.1007/s00262-021-02981-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Immunohistochemical analysis of FOXP3 and CD8 protein expression in representative example cases of the study cohort. Positive cells were quantified as percentage of all (tumor and stroma) cells. a Comparison of ALK-positive tumors with high Treg mRNA marker and ALK-negative tumors with low Treg mRNA marker. The percentage of FOXP3-positive cells was significantly higher in the ALK-positive tumors (mean: 1.84%) than in ALK-negative tumors (mean: 0.96%). b Comparison of EGFR-positive tumors with low cytotoxic cell mRNA marker and EGFR-negative tumors with high cytotoxic cell mRNA marker. The percentage of CD8-positive cells was significantly lower in the EGFR-positive tumors (mean: 9%) compared to the EGFR-negative tumors (mean: 40%)