Table 2.
Correlation between bone mineral status/vertebral fractures and main clinical, virological and biochemical data
| Spine BMD | Spine T-score |
Total hip BMD | Total hip T-score | Femoral neck BMD | Femoral neck T-score | Vertebral fractures | |
|---|---|---|---|---|---|---|---|
| Age (years) | 0.08 | 0.09 | 0.04 | 0.04 | 0.05 | 0.05 | 0.15* |
| BMI (kg/m2) | 0.23** | 0.24** | 0.37** | 0.35** | 0.23* | 0.32** | – 0.06 |
| HIV infection duration (years) | – 0.12 | – 0.16* | – 0.30** | – 0.29** | – 0.08 | – 0.15 | 0.19* |
| cART duration (years) | - 0.10 | – 0.11 | – 0.20 | – 0.22* | 0.01 | – 0.10 | 0.25** |
| CD4 + (cell/mm3) nadir | 0.04 | 0.07 | 0.22* | 0.14 | 0.10 | 0.08 | – 0.08 |
| CD4 + (cell/mm3) at inclusion | – 0.01 | 0.08 | 0.22* | 0.17 | 0.17 | 0.13 | 0.01 |
| TT (ng/ml) | – 0.11 | – 0.11 | – 0.30** | – 0.27** | – 0.18 | – 0.17* | 0.08 |
| SHBG (nmol/l) | – 0.23* | – 0.25** | – 0.22 | – 0.29* | – 0.08 | – 0.19* | 0.29** |
| cFT (pg/ml) | 0.09 | 0.06 | – 0.08 | – 0.06 | 0.05 | 0.02 | – 0.06 |
| LH (IU/l) | – 0.08 | – 0.11 | – 0.22 | – 0.25* | – 0.02 | – 0.17 | 0.10 |
| FSH (IU/l) | – 0.02 | – 0.03 | – 0.27** | – 0.29** | – 0.14 | – 0.21* | 0.08 |
| Calcium (mg/dl) | – 0.10 | – 0.13 | – 0.07 | – 0.08 | 0.06 | – 0.10 | 0.01 |
| 25-OH-vitamin D (ng/ml) | 0.05 | – 0.02 | 0.02 | 0.04 | 0.03 | – 0.01 | 0.15 |
| PTH (pg/ml) | 0.01 | 0.02 | 0.07 | – 0.04 | – 0.11 | – 0.10 | 0.03 |
Spearman correlation was used for continuous-continuous variables correlation; point-biserial correlation was used for continuous-categorical variables correlation
*Correlation is significant at p = 0.05 (two-tail)
**Correlation is significant at p = 0.01 (two-tail)
Abbreviations: BMI body mass index, cART combined antiretroviral therapy, TT total testosterone, SHBG sex hormone-binding protein, cFT calculated free testosterone, LH luteinizing hormone, FSH follicle stimulating hormone, PTH parathyroid hormone, BMD bone mineral density