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. 2021 Jun 28;71(2):399–415. doi: 10.1007/s00262-021-02995-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Process of screening the target gene and SFTPA1 expression pattern in human tissues. a Venn diagram of genes selected by the NSCLC gene set from the TCGA database and immune gene set from ImmPort. b & c Volcano plot of the differential gene expression in the tumor vs adjacent normal comparison in LUSC b and LUAD c (P < 0.01, fold-change > 1). d The level of SFTPA1 mRNA expression in various human tumors and adjacent normal tissues in TIMER across all TCGA tumors (P-value Significant Codes: 0 ≤ *** < 0.001 ≤ ** < 0.01 ≤ * < 0.05 ≤ . < 0.1). e The SFTPA1 protein expression pattern in 15 human tumors and adjacent normal tissues by immunohistochemistry. BLCA, bladder urothelial carcinoma; BRCA, breast invasive carcinoma; CESC, cervical squamous cell carcinoma; COAD, colon adenocarcinoma; ESCA, esophageal carcinoma; HNSC, head and neck squamous cell carcinoma; KIRC, kidney renal clear cell carcinoma; LIHC, liver hepatocellular carcinoma; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; PRAD, prostate adenocarcinoma; READ, rectum adenocarcinoma; SKCM, skin cutaneous melanoma; STAD, stomach adenocarcinoma; THCA, thyroid carcinoma