Table 4:

Multivariable Analysis of Characteristics Associated with Mortality, Persistent Bacteremia, and Metastatic Complications in Hemodialysis (HD)-Dependent Patients

	All-Cause Mortalitya	SABb-Attributable Mortalitya	Persistent Bacteremiaa	Metastatic Complicationsa
# of Events (%)	106 (23.4)	60 (13.2)	140 (30.9)	160 (35.3)
Variable	Odds Ratio (95% Confidence Interval)
Genotype
MSSA	Reference
non-USA300 MRSA	2.27 (1.36, 3.80)	1.78 (0.95, 3.36)	3.55 (2.21, 5.69)	1.56 (1.01, 2.43)
USA300	0.44 (0.10, 1.88)	0.83 (0.19, 3.61)	2.96 (1.12, 7.83)	1.34 (0.53, 3.41)
Age
<45 Years	Reference
45-54 Years	1.46 (0.59, 3.63)	1.49 (0.44, 5.14)	1.23 (0.60, 2.54)	1.10 (0.57, 2.11)
55-64 Years	2.30 (0.99, 5.22)	2.41 (0.80, 7.23)	1.34 (0.66, 2.70)	0.95 (0.50, 1.82)
65+ Years	2.65 (1.18, 5.95)	3.42 (1.17, 10.03)	1.74 (0.88, 3.43)	1.12 (0.60, 2.08)
Gender
Male	Reference
Female	1.04 (0.63, 1.72)	0.94 (0.51, 1.74)	1.01 (0.65, 1.58)	0.77 (0.50, 1.16)
Race
Non-Hispanic White	Reference
Black	0.71 (0.40, 1.28)	0.49 (0.25, 0.94)	1.58 (0.90, 2.80)	0.82 (0.49, 1.37)
Other	2.04 (0.43, 9.76)	2.33 (0.43, 12.49)	6.62 (1.52, 28.91)	2.53 (0.64, 9.96)
Comorbidities
Diabetes Mellitus	0.99 (0.59, 1.68)	0.86 (0.46, 1.61)	1.08 (0.68, 1.73)	1.44 (0.92, 2.26)
Neoplasm	1.91 (0.77, 4.78)	0.64 (0.17, 2.45)	0.44 (0.15, 1.27)	0.22 (0.07, 0.73)
Transplantation	0.67 (0.20, 2.17)	0.54 (0.11, 2.76)	0.91 (0.35, 2.35)	0.46 (0.18, 1.16)
Corticosteroid use	0.72 (0.27, 1.95)	0.61 (0.16, 2.37)	2.39 (1.11, 5.18)	3.66 (1.72, 7.80)
Foreign Body Central Venous Catheter	1.65 (0.75, 3.60)	1.27 (0.52, 3.12)	0.93 (0.45, 1.92)	0.84 (0.42, 1.66)
Site of acquisition
HAc	Reference
CA-HCAd	0.25 (0.12, 0.53)	0.39 (0.17, 0.88)	0.89 (0.42, 1.87)	1.82 (0.85, 3.93)
Source of Infection e
Central Venous Catheter	Reference
Arteriovenous graft	1.03 (0.38, 2.80)	1.69 (0.54, 5.30)	1.20 (0.50, 2.87)	0.70 (0.31, 1.62)
Arteriovenous fistula	1.36 (0.28, 6.66)	2.65 (0.50, 13.90)	0.30 (0.07, 1.35)	1.51 (0.48, 4.73)
Non-Vascular Accessf	3.34 (1.60, 6.97)	3.20 (1.36, 7.55)	2.11 (1.05, 4.22)	1.51 (0.79, 2.91)

^aResults for each variable are adjusted for all other variables shown. Odds ratios and confidence intervals marked in bold are significant

^bStaphylococcus aureus bacteremia

^cHospital-acquired

^dCommunity-acquired, healthcare associated

^eSuspected source of infection

^fIncludes: abscess, septic arthritis, biliary tract, burn, arterial catheter, intra-aortic balloon pump, peripheral catheter, other non-central venous catheter, cellulitis, decubitus ulcer, dermatitis, empyema, foot/leg ulcer, furuncle, gangrene, intravenous drug use, mediastinitis, percutaneous nephrostomy, peritoneal dialysis catheter, pneumonia, sinusitis, wound, and unknown/unspecified source of infection