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. 2021 Dec 5;13(2):102–119. doi: 10.1007/s13238-021-00890-3

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© The Author(s) 2022, corrected publication 2022

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A model showing that epigenetic integrity of paternal DMRs enhances the developmental potential of AG-haESCs. Schematic of epigenetic features of paternal DMRs in TSa2i/L-treated AG-haESCs (upper) and 2i-SF/a2i-switched AG-haESCs (bottom). Open and filled circles represent unmethylated and methylated CpG sites, respectively