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Regulation of cGAS nuclear translocation. Cytosolic cGAS may translocate into the nucleus via an importin α-dependent mechanism, which is stimulated by DNA damage but inhibited by BLK-mediated phosphorylation. cGAS could also translocated to the nucleus during mitosis when the nuclear envelop (NE) is broken. Nuclear cGAS could also be exported to cytosol through Exportin 1. The translocation mechanism of cGAS is related to its distinct function in cellular sublocation
