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IL-17a regulates fecal α-defensin produced by Paneth cells. α-defensin concentration in the feces of WT (n = 34) or Rag1-deficient (n = 22) mice (A), WT (n = 14) or IFN-γ–deficient (n = 21) mice (B), and WT (n = 21) or IL-17a–deficient (n = 20) mice (C) was measured with an ELISA. Data are presented as mean ± SD *P < 0.05, ***P < 0.001, Student’s t test.
