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Carrier frequencies of pathogenic sequence variants in lethal and indolent cases summarized by DNA damage response (DDR) pathway. A) Full DDR gene panel. B) DDR gene panel excluding BRCA2. C) Gene panel from Pritchard et al (3). BER = base excision repair; DR = direct repair; FA = Fanconi anemia; HR = homologous recombination; MMR = mismatch repair; NER = nucleotide excision repair; NHEJ = nonhomologous end joining; TLS = translesion synthesis.
