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Carrier frequencies of pathogenic sequence variants in lethal cases diagnosed younger than 65 years, lethal cases diagnosed at 65 years and older, and indolent cases summarized by DNA damage response (DDR) pathway. BER = base excision repair; DR = direct repair; FA = Fanconi anemia; HR = homologous recombination; MMR = mismatch repair; NER = nucleotide excision repair; NHEJ = nonhomologous end joining; TLS = translesion synthesis.
