Table 2.

DNA damage response genes with pathogenic sequence variants in men with lethal and indolent prostate cancer^a

Core DDR pathways								Noncore DDR pathways
HR	FA	NHEJ	MMR	NER	BER	TLS	DR	Check-point factor	Other noncore	Probable associated
BLM	BARD1	APTX	EXO1	DDB2	APTX	POLH	ASCC1	ATM	BLM	CCNO
BRCA2	BLM	ATM	MLH1	ERCC2	MUTYH			ATR	MRE11	POLG
MRE11	BRCA2	DCLRE1C	MLH3	ERCC3	NTHL1			PER2	NBN	VCP
NBN	BRIP1	MRE11	MSH2	ERCC5	PNKP			RAD50	RAD50
RAD50	FANCA	NBN	MSH6	ERCC8	POLE			RBBP8	TP53
RAD51	FANCI	PNKP	PMS2	POLE	POLH
RAD51C	RAD51	RAD50		XPA	UNG
RAD54B	RAD51C	XRCC1		XRCC1	XRCC1
RAD54L		XRCC4
RECQL4
SLX4
UIMC1

^aBER = base excision repair; DDR = DNA damage response; DR = direct repair; FA = Fanconi anemia; HR = homologous recombination; MMR = mismatch repair; NER = nucleotide excision repair; NHEJ = nonhomologous end joining; TLS = translesion synthesis.