Table 8. Differences of mean scores of subscales: Comparisons between two known-groups with the Karnofsky Performance Status score ≧70 or <70 subgroups among patients completed questionnaires prior to their first cycle of treatment (T1), and the second column is among patients completed questionnaires on the last day of the first cycle of treatment (T2).

Scales/items	T1		T2
	Difference	p	Difference	p
physical functioning (PF)	-22.0	0.0116	-21.1	0.0001
role functioning (RF)	-24.2	0.0006	-15.0	0.0216
emotional functioning (EF)	-12.3	0.0236	-14.1	0.0035
cognitive functioning (CF)	-11.8	0.0386	-14.2	0.0157
social functioning (SF)	-20.4	0.0014	-8.6	0.1427
global health/QOL (QL)	-10.5	0.0467	-6.1	0.1560
fatigue (FA)	23.5	0.0000	18.0	0.0020
nausea and vomiting (NV)	11.6	0.0793	12.7	0.0640
pain (PA)	17.2	0.0526	20.3	0.0033
dyspnea (DY)	11.2	0.2098	14.9	0.0090
sleep disturbance (SL)	14.4	0.0310	16.9	0.0056
appetite loss (AP)	23.1	0.0013	20.8	0.0008
constipation (CO)	17.8	0.0087	9.0	0.1875
diarrhea (DI)	-2.4	0.6237	-6.2	0.2220
financial impact (FI)	9.4	0.2046	4.3	0.5096