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. 2022 Jan 19;15:439–450. doi: 10.2147/JIR.S345664

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© 2022 Chen et al.

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The results of bioinformatics analysis. (A) The top 50 DEGs identified by R software. The highly expressed genes in NP group were represented by the red areas and lowly expressed were represented by the green areas. (B) Volcano plot. Red dots represent the up-regulated genes and blue dots represent the down-regulated genes. (C) The top 10 key genes of DEGs identified by cytohubba. (D) The degree of the top 10 key genes was listed by R software. (E) GO functional enrichment result of DEGs. (F) KEGG functional enrichment result of DEGs. (G) EGF was highly enriched in “WNT-activated receptor activity” (ES=0.57, NES =1.65, p<0.05) according to GSEA. (H) The heatmap of GSEA showed genes distribution of “WNT-activated receptor activity”.

Abbreviations: DEGs, differentially expressed genes; NP, nasal polyps; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; GSEA, gene set enrichment analysis; ES, enrichment score; NES, normalized enrichment score.