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. 2021 Oct 25;102(2):143–153. doi: 10.1038/s41374-021-00682-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Representative graphs showing cell cycle distribution. b The statistical results of the cell cycle distribution (G1, G2, and S) of SW1088 (up) and SW1783 (down) cells in the control and si1303 groups. c Representative graphs showing the effect of U73122 on early and late apoptosis by annexin V–PI flow cytometry assays. d The statistical results of the SW1088 (up) and SW1783 cell (down) apoptosis assays. e The Western blot verified the flow cytometry results of cell cycle and apoptosis. f The statistical results of the Western blot in the control and si1303 groups of CDK1 and Caspase3. ***p < 0.001, **p < 0.01, *p < 0.05. The data are expressed as the means ± SD.