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. 2021 Oct 25;102(2):143–153. doi: 10.1038/s41374-021-00682-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Time course of U731222 treatment in the mouse subcutaneous SW1088/Luc xenograft model. b Representative images of tumor bioluminescence intensity after SW1088/Luc inoculation after 10, 14, 18, 22, 28, and 34 days. c The statistical results of the photon flux of SW1088/Luc xenograft models. d The statistical results of the body weights of SW1088/Luc xenograft models. e The statistical results of the relative tumor volume of SW1088/Luc xenograft models. f Representative IHC image of samples from xenograft model in different groups (upper); Magnification of yellow rectangular area (lower). Scale bar = 50 μm (upper three images) or 10 μm (lower three images). g The statistical results of the H-score of PLCG1 protein. **p < 0.01, *p < 0.05. Data are expressed as the mean ± SD.