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. 2022 Jan 10;12:781623. doi: 10.3389/fphar.2021.781623

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Copyright © 2022 Li, Zhang, Ren, Gao and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Suppression of tumor growth by NVP-BEZ235, PP242 and Rapamycin in vivo. Subcutaneous RCC tumors were established by injection of 786-0 or A498 cells into nude mice. The treatment with NVP-BEZ235, PP242, and Rapamycin (15 mg/kg) started after the tumor size reached around 300 mm³. All mice were sacrificed 28 days post injection. (A) Tumors were excised from the flank of these mice (n = 6/group). (B) Body weight and (C) tumor volume of A498 and 786-0 xenografts were measured periodically. A group of untreated mice served as control. Results are means ± SD of 6 different mice.