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Inhibition of the activity of TAK1, c-Jun, and IκB-α in RCC xenografts in response to treatment by NVP-BEZ235, PP242, and Rapamycin. Sections of all xenograft tumor tissues formed by (A) 786-0 and (B) A498 renal cancer cells were examined by immunohistochemical staining using anti-p-TAK1, anti-p-c-Jun, and anti-p-IκB-α antibodies. Representative images were taken at a magnification 200× (inset 400×). A group of untreated mice served as control.
