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. 2022 Jan 10;8:814951. doi: 10.3389/fmed.2021.814951

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Copyright © 2022 Fridén, Rosqvist, Ahlström, Niessen, Schultheis, Hockings, Hulthe, Gummesson, Wanders, Rorsman, Risérus and Vessby.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proportions of liver fatty acids between F0–1 and F2–4. Data are expressed as means ± SEM. Black bars represent fibrosis stages 0–1 (F0–1) and white bars represent fibrosis stages (F2–4), as indicated by the legend in the top left corner of the first bar graph. Due to large differences in proportions of fatty acids, each lipid fraction is divided into two separate graphs to enhance visibility. 14:0, myristic acid; 15:0, pentadecaenoic acid; 16:0, palmitic acid; 16:1n-7, palmitoleic acid; 17:0, heptadecaenoic acid; 18:0, stearic acid; 18:1n-9, oleic acid; 18:1n-7, vaccenic acid; 18:1, oleic acid combined with vaccenic acid; 18:2n-6, linoleic acid; 18:3n-6, γ-linolenic acid; 18:3n-3, α-linolenic acid; 20:0, arachidic acid; 20:3n-6, dihomo-γ-linolenic acid; 20:4n-6, arachidonic acid; 20:5n-3, eicosapentaenoic acid; 22:0, behenic acid; 22:5n-3, docosapentaenoic acid; 22:6n-3, docosahexaenoic acid; 24:0, lignoceric acid; SCD-1, stearoyl-coA desaturase; D5D, delta 5 desaturase; D6D, delta 6 desaturase; AA/LA, arachidonic acid/linoleic acid. SCD-1, D5D and D6D are estimated using fatty acid product-to-precursor ratios: 16:1n-7/16:0 (SCD-1), 20:4n-6/20:3n-6 (D5D), 18:3n-6/18:2n-6 (D6D). **n(F0–1) = 19, n(F2–4) = 16 due to 25 zero-values of 20:3n-6.