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. 2022 Jan 10;9:784199. doi: 10.3389/fcell.2021.784199

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Copyright © 2022 Liu, Guo, Yang, Chen, Fan, Wu, Si, Xu, shao, Chen, Dang, Cui, Han, Ji and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The clinical significance of the two immune subtypes in the meta-GEO cohort. (A–H) Composition percentages of clinical characteristics such as age (A), gender (B), T stage (C), N stage (D), M stage (E), AJCC stage (F), MSI (G), and 5-FU response (H) between C1 and C2. (I) The IC50 distribution of Cisplatin between two subtypes. (J) Composition percentages of immunotherapy response estimated by TIDE algorithm between C1 and C2. (K) Submap analysis revealed that C2 was sensitive to immunotherapy.