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. 2022 Jan 24;3(2):100522. doi: 10.1016/j.xcrm.2022.100522

Figure 1.

Figure 1

Tissue- and duration-specific dysregulation of gene expression from SARS-CoV-2 infection

(A) Sample overview by tissue for RNA-seq and GeoMx experiments. Number of regions of interest (ROIs) and patient numbers (n) are summarized, and a representative tissue slide image for GeoMX spatial profiling is presented along with the tissue types.

(B) Volcano plots of the COVID-19-positive versus normal tissues are shown for the five tissues from autopsy: heart (n = 41), kidney (n = 27), liver (n = 40), lung (n = 40), and lymph node (n = 27). Differentially expressed genes (>1.5-fold, q < 0.05, DESeq2) are shown as purple spots (downregulated in COVID-19) and orange (upregulated in COVID-19).