Table 4.
Mediation of proteins on the association between RDW and all-cause mortality in anemia-free adults (sorted by p-value in indirect association).
| Mediator |
Total association of RDW with all-cause mortality |
Direct association of RDW with all-cause mortality |
Indirect association of RDW with all-cause mortality through mediator |
Proportion mediated | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rank | Target | Entrez Gene |
β | 95%CI | p-value | β | 95%CI | p-value | β | 95%CI | p-value | ||||
| Cross-sectional analysis† | |||||||||||||||
| 1 | ERBB1 | EGFR | 0.85 | 0.76 | 0.94 | 0.002 | 0.88 | 0.79 | 0.98 | 0.02 | 0.96 | 0.94 | 0.99 | 0.01 | 52.8% |
| 2 | Growth hormone receptor | GHR | 0.84 | 0.75 | 0.93 | 0.002 | 0.87 | 0.79 | 0.97 | 0.01 | 0.96 | 0.93 | 0.99 | 0.01 | 53.0% |
| 3 | TrkC | NTRK3 | 0.85 | 0.76 | 0.94 | 0.003 | 0.87 | 0.78 | 0.97 | 0.01 | 0.97 | 0.95 | 0.99 | 0.02 | 51.0% |
| 4 | IGFBP-2 | IGFBP2 | 0.85 | 0.76 | 0.94 | 0.002 | 0.86 | 0.77 | 0.96 | 0.01 | 0.98 | 0.97 | 0.997 | 0.02 | 48.9% |
| 5 | Mn SOD | SOD2 | 0.86 | 0.77 | 0.95 | 0.004 | 0.88 | 0.79 | 0.98 | 0.02 | 0.97 | 0.95 | 0.996 | 0.02 | 51.2% |
| 6 | KLRF1 | KLRF1 | 0.84 | 0.76 | 0.94 | 0.001 | 0.86 | 0.78 | 0.96 | 0.01 | 0.98 | 0.96 | 0.997 | 0.02 | 49.7% |
| 7 | TSP2 | THBS2 | 0.85 | 0.76 | 0.94 | 0.002 | 0.86 | 0.77 | 0.96 | 0.01 | 0.98 | 0.97 | 0.998 | 0.03 | 48.4% |
| 8 | TIMP-1 | TIMP1 | 0.85 | 0.76 | 0.94 | 0.002 | 0.86 | 0.77 | 0.95 | 0.004 | 0.99 | 0.98 | 0.999 | 0.03 | 48.0% |
| 9 | N-terminal pro-BNP | NPPB | 0.85 | 0.77 | 0.95 | 0.003 | 0.86 | 0.78 | 0.96 | 0.01 | 0.99 | 0.97 | 0.999 | 0.03 | 48.4% |
| 10 | C9 | C9 | 0.85 | 0.76 | 0.94 | 0.002 | 0.86 | 0.77 | 0.96 | 0.01 | 0.98 | 0.96 | 0.999 | 0.04 | 49.0% |
| Longitudinal analysis‡ | |||||||||||||||
| 1 | C7 | C7 | 0.26 | 0.06 | 1.18 | 0.08 | 0.36 | 0.08 | 1.70 | 0.20 | 0.71 | 0.51 | 0.997 | 0.048 | 29.4% |
| 2 | IGFBP-2 | IGFBP2 | 0.22 | 0.05 | 0.96 | 0.04 | 0.28 | 0.06 | 1.24 | 0.09 | 0.78 | 0.61 | 1.01 | 0.055 | 23.2% |
Protein-specific accelerated failure time model with exponetial estimation. RDW-mediator (one protein) associations were modeled with multivariable linear regression model. All models were adjusted for age, sex, body mass index, smoking status (current smoker or not), education level (6-year education or higher education or not), and haemoglobin.
RDW and proteins were measured at baseline. Outcome was 15-year all-cause mortality.
Longitudinal changes in RDW and proteins were calculated from {(9-year follow-up visit - baseline visit)/exact time intervals in each participant}. Outcome was 6-year all-cause mortality from 9-year follow-up visit.