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. 2022 Jan 10;11:812643. doi: 10.3389/fonc.2021.812643

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Copyright © 2022 Lerner, Medin, Jamtheim Gustafsson, Alkner and Olsson

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prospective (A) and retrospective (B) analysis of dose difference between treatment plans calculated on sCT and CT images for target (PTV and GTV) and organs at risk (OAR) brainstem and chiasma for all patients. In the prospective results, OAR outliers outside ±1% had relative dose levels more than 10% below the clinical tolerance for absorbed dose to OARs. In the additional retrospective analysis, original dose distribution has been corrected for image rotations and image resolution differences between the sCT and CT. The thick black line in each box represents the median value for all patients. The box includes the 25th-75th percentiles, the interquartile range (IQR). Whiskers represent the maximum and minimum values within 1.5 IQR and the crosses represent any values outside that range. The grey horizontal lines represent ±1% dose difference.