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. 2022 Jan 10;11:814085. doi: 10.3389/fonc.2021.814085

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Copyright © 2022 Wei, Xu, Wang and Tong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development of single cell metabolite extraction. (A) Microsyringes composed of glass straws were firstly used to extract metabolites from giant neuron cells of snails (1988); (B) Nanospray ionization captures the sample from a single living cell, and this process is controlled by a cell manipulation system (2008); (C) A nanotube that can measure glucose levels in single-cell level (2011); (D) The Single-probe coupled with a sampling tip size < 10 μm, is a miniaturized multifunctional sampling and ionization tool which can achieve in situ metabolomic analysis of individual living cells with real-time performance (2014); (E) The micropipette needle accommodated with PB reactions inside to determine C=C bond locations in unsaturated lipids at single-cell level (2020).