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. 2022 Jan 10;11:814085. doi: 10.3389/fonc.2021.814085

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Copyright © 2022 Wei, Xu, Wang and Tong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comprehensive exploration of the heterogeneity of HCC analysis scheme. Through single-cell sequencing, HCC could be classified as three subtypes according to the expression level of marker genes PTPRC and FOXP3. Further single-cell metabolomic analysis revealed that the immunocompetent subtype is with upregulated urea cycle, the immunosuppressive subtype is with upregulated TCA cycle and inhibited glycolysis pathway, and the immunodeficient subtype presents upregulated nucleotide biosynthesis pathway.